Summit Therapeutics (SMMT) has had the highest return between 2022 and 2025 by a large-cap US stock, returning 830.5%.

ASSET	YEARS	% RETURN
Summit Therapeutics (SMMT)	2022-2025	830.53%
Super Micro Computer (SMCI)	2022-2025	735.46%
YPF Sociedad Anonima (YPF)	2022-2025	716.88%
Grupo Financiero Galicia SA ADR (GGAL)	2022-2025	695.74%
Celestica (CLS)	2022-2025	687.79%
MicroStrategy (MSTR)	2022-2025	570.62%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	524.46%
Constellation Energy (CEG)	2022-2025	509.59%
Vistra Energy (VST)	2022-2025	509.41%
Sprouts Farmers Market LLC (SFM)	2022-2025	471.97%
Fortress Transp & Infra Inv (FTAI)	2022-2025	394.15%
TechnipFMC (FTI)	2022-2025	377.69%
Fair Isaac (FICO)	2022-2025	344.53%
Howmet Aerospace (HWM)	2022-2025	330.55%
Flex (FLEX)	2022-2025	319.1%
Comfort Systems USA (FIX)	2022-2025	302.75%
Alamos Gold (AGI)	2022-2025	285.06%
Axon Enterprise (AXON)	2022-2025	284.71%
MakeMyTrip (MMYT)	2022-2025	273.57%
Targa Resources (TRGP)	2022-2025	268.64%
NVIDIA (NVDA)	2022-2025	265.3%
Duolingo (DUOL)	2022-2025	261.22%
Reddit (RDDT)	2022-2025	256.5%
Unum (UNM)	2022-2025	255.72%
Texas Pacific Land Trust (TPL)	2022-2025	244.1%

Large-cap stocks are treated as having a market cap of $10B+.