Rhythm Pharmaceuticals (RYTM) had the highest return in Q3 2022 by a US stock with a market cap of $2B+, returning 500.5%.

ASSET	QUARTER	% RETURN
Rhythm Pharmaceuticals (RYTM)	Q3 2022	500.49%
Verona Pharma PLC ADR (VRNA)	Q3 2022	146.86%
Enovix (ENVX)	Q3 2022	104.18%
Marathon Digital (MARA)	Q3 2022	97.97%
First Solar (FSLR)	Q3 2022	95.72%
YPF Sociedad Anonima (YPF)	Q3 2022	90.49%
Dyne Therapeutics (DYN)	Q3 2022	84.59%
Catalyst Pharmaceuticals (CPRX)	Q3 2022	83.55%
Calix (CALX)	Q3 2022	80.94%
Xometry (XMTR)	Q3 2022	67.77%
Wingstop (WING)	Q3 2022	66.86%
Riot Blockchain (RIOT)	Q3 2022	65.33%
Sweetgreen (SG)	Q3 2022	59.21%
Empresa Distribuidora y Comercializadora Norte SA ADR (EDN)	Q3 2022	59.14%
Torm PLC Class A (TRMD)	Q3 2022	58.68%
Vera Therapeutics (VERA)	Q3 2022	56.58%
Fluence Energy (FLNC)	Q3 2022	54.39%
Payoneer Global (PAYO)	Q3 2022	53.55%
Penumbra (PEN)	Q3 2022	52.42%
Weatherford International (WFRD)	Q3 2022	52.38%
Geron (GERN)	Q3 2022	50.97%
Apellis Pharmaceuticals (APLS)	Q3 2022	50.57%
Sarepta Therapeutics (SRPT)	Q3 2022	48.24%
Extreme Networks (EXTR)	Q3 2022	48.02%
MoonLake Immunotherapeutics (MLTX)	Q3 2022	47.81%