Regeneron Pharmaceuticals (REGN) had the highest return between 2008 and 2012 by a US stock in the S&P 500 (GSPC), returning 612.2%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2008-2012	612.2%
Ulta Beauty (ULTA)	2008-2012	484.47%
Booking (BKNG)	2008-2012	431.38%
Tractor Supply (TSCO)	2008-2012	406.78%
Dollar Tree (DLTR)	2008-2012	369.44%
Ross Stores (ROST)	2008-2012	349.07%
Edwards Lifesciences (EW)	2008-2012	294.43%
Transdigm (TDG)	2008-2012	291.1%
Tyler Technologies (TYL)	2008-2012	277.26%
Domino's Pizza Inc Common Stock (DPZ)	2008-2012	255.96%
Generac (GNRC)	2008-2012	251.61%
Netflix (NFLX)	2008-2012	248.6%
F5 Networks (FFIV)	2008-2012	246.72%
Old Dominion Freight Line (ODFL)	2008-2012	239.77%
LyondellBasell Industries (LYB)	2008-2012	231.79%
Lululemon Athletica (LULU)	2008-2012	221.65%
TJX Companies (TJX)	2008-2012	216.37%
MarketAxess (MKTX)	2008-2012	203.51%
Smith AO (AOS)	2008-2012	198.17%
Sherwin-Williams (SHW)	2008-2012	195.67%
AutoZone (AZO)	2008-2012	195.11%
Estee Lauder Companies (EL)	2008-2012	192.85%
Warner Bros Discovery (WBD)	2008-2012	180.05%
O’Reilly Automotive (ORLY)	2008-2012	177.01%
Discover Financial Services (DFS)	2008-2012	169.93%