Clene (CLNN) had the highest return between 2009 and 2021 by a US stock, returning 6,833,233.3%.

ASSET	YEARS	% RETURN
Clene (CLNN)	2009-2021	6,833,233.33%
Crown Electrokinetics (CRKN)	2009-2021	3,989,900%
HIVE Blockchain Technologies (HIVE)	2009-2021	2,639,900%
XORTX Therapeutics (XRTX)	2009-2021	1,044,239.62%
authID (AUID)	2009-2021	897,820%
Bragg Gaming (BRAG)	2009-2021	838,233.33%
Scinai Immunotherapeutics (SCNI)	2009-2021	469,900%
Zhihu Inc ADR (ZH)	2009-2021	455,242.47%
Fresh2 (FRES)	2009-2021	433,292.54%
Luokung Technology (LKCO)	2009-2021	348,101.44%
Ryvyl (RVYL)	2009-2021	322,976.92%
Immatics (IMTX)	2009-2021	268,700%
KWESST Micro Systems Inc Common Stock (KWE)	2009-2021	86,695.35%
American Lithium Corp Common Stock (AMLI)	2009-2021	83,650%
Connexa Sports Technologies (YYAI)	2009-2021	68,700%
Xpel (XPEL)	2009-2021	64,928.57%
Issuer Direct (ISDR)	2009-2021	46,279.53%
CEA Industries (CEAD)	2009-2021	38,300%
Skye Bioscience, Inc Common Stock (SKYE)	2009-2021	32,400%
Sleep Number (SNBR)	2009-2021	29,361.54%
Avis Budget (CAR)	2009-2021	29,106%
Tesla (TSLA)	2009-2021	27,709.27%
Aurinia Pharmaceuticals (AUPH)	2009-2021	27,289.22%
Nexstar Broadcasting (NXST)	2009-2021	26,625.07%
Nova (NVMI)	2009-2021	26,536.36%