Portage Biotech (PRTG) had the highest return between 2000 and 2001 by a US stock, returning 28,956.6%.

ASSET	YEARS	% RETURN
Portage Biotech (PRTG)	2000-2001	28,956.6%
Xcel Brands (XELB)	2000-2001	9,999.96%
Tritium Dcfc (DCFC)	2000-2001	5,592.31%
Versus Systems Inc. (VS)	2000-2001	2,300%
Flotek Industries (FTK)	2000-2001	1,733.33%
RadNet (RDNT)	2000-2001	1,523.53%
Algorhythm (RIME)	2000-2001	1,108.53%
CarMax (KMX)	2000-2001	910.67%
Option Care Health (OPCH)	2000-2001	630.26%
Accelerate Diagnostics (AXDX)	2000-2001	581.6%
FTI Consulting (FCN)	2000-2001	556.01%
US Physicalrapy (USPH)	2000-2001	478.85%
NVIDIA (NVDA)	2000-2001	466.74%
Avid Bioservices (CDMO)	2000-2001	462.9%
Flexible Solutions International (FSI)	2000-2001	460.03%
Amedisys (AMED)	2000-2001	409.12%
Caesars Entertainment (CZR)	2000-2001	401.96%
Itron (ITRI)	2000-2001	399.79%
Mednax (MD)	2000-2001	384.57%
Meritage (MTH)	2000-2001	377.21%
Quest Diagnostics (DGX)	2000-2001	365.46%
Integra LifeSciences (IART)	2000-2001	345.98%
Laboratory Corporation of America (LH)	2000-2001	338.46%
BJs Restaurants (BJRI)	2000-2001	337.07%
NVR (NVR)	2000-2001	327.23%