LakeShore Biopharma (LSB) had the highest return in December 2021 by a US stock, returning 904.1%.

ASSET	MONTH	% RETURN
LakeShore Biopharma (LSB)	December 2021	904.13%
Imperial Petroleum (IMPP)	December 2021	434.93%
Lendway (LDWY)	December 2021	334.65%
Reliance Global (RELI)	December 2021	206.67%
Ensysce Biosciences (ENSC)	December 2021	195.6%
Ucloudlink (UCL)	December 2021	154.44%
Jowell Global (JWEL)	December 2021	122.62%
Energy Services Of America (ESOA)	December 2021	120%
ReTo Eco-Solutions (RETO)	December 2021	97.67%
Dogness International Corp Class A (DOGZ)	December 2021	96.5%
Cerberus Cyber Sentinel (CISO)	December 2021	94.81%
Foghorn Therapeutics (FHTX)	December 2021	91.38%
Next Technology (NXTT)	December 2021	90.48%
Vasta Platform (VSTA)	December 2021	86.34%
Palladyne AI (PDYNW)	December 2021	86.24%
Huadi International (HUDI)	December 2021	79.63%
Pop Culture (CPOP)	December 2021	79.53%
Nutriband Inc Warrant (NTRBW)	December 2021	78.22%
Energy Focu (EFOI)	December 2021	77.18%
Netcapital (NCPL)	December 2021	76.47%
Spruce Biosciences (SPRB)	December 2021	74.22%
Firefly Neuroscience (AIFF)	December 2021	70.69%
Biofrontera Inc Warrants (BFRIW)	December 2021	65.14%
Mega Matrix (MPU)	December 2021	64.01%
Adicet Bio (ACET)	December 2021	63.61%