NRx Pharmaceuticals (NRXPW) had the highest return in Q4 2020 by a small-cap US stock, returning 1,780%.

ASSET	QUARTER	% RETURN
NRx Pharmaceuticals (NRXPW)	Q4 2020	1,780%
Bitfarms (BITF)	Q4 2020	691.67%
HIVE Blockchain Technologies (HIVE)	Q4 2020	540.68%
Innoviz Technologies (INVZW)	Q4 2020	520.97%
Bit Digital (BTBT)	Q4 2020	433.09%
HighPeak Energy (HPKEW)	Q4 2020	417.71%
Mind Medicine (MNMD)	Q4 2020	396.5%
Jumia Technologies (JMIA)	Q4 2020	395.7%
Nouveau Monde Graphite (NMG)	Q4 2020	387.59%
Eos Energy Enterprises (EOSEW)	Q4 2020	380.35%
Advent Technologies (ADNWW)	Q4 2020	363.01%
Gevo (GEVO)	Q4 2020	325%
Nano Dimension (NNDM)	Q4 2020	279.96%
Quantum Computing (QUBT)	Q4 2020	278.79%
Arvinas (ARVN)	Q4 2020	258.35%
Katapult Holdings Equity Warrants Exp 09 June 2026 (KPLTW)	Q4 2020	254.31%
Red Cat (RCAT)	Q4 2020	252.94%
Canaan (CAN)	Q4 2020	217.11%
Clean Energy Fuels (CLNE)	Q4 2020	216.94%
Fubotv (FUBO)	Q4 2020	209.39%
Precigen (PGEN)	Q4 2020	191.43%
Clearpoint Neuro (CLPT)	Q4 2020	191.03%
Danaos (DAC)	Q4 2020	186.12%
Centrus Energy (LEU)	Q4 2020	172.44%
Intellia Therapeutics (NTLA)	Q4 2020	170.92%

Small-cap stocks are treated as having a market cap between $300M and $2B.