best performing small cap stocks from 2015 to 2021

Immatics (IMTX) had the highest return between 2015 and 2021 by a small-cap US stock, returning 268,700%.

ASSET YEARS % RETURN
Immatics (IMTX)
2015-2021
268,700%
Applied Digital (APLD)
2015-2021
43,095.88%
eXp World (EXPI)
2015-2021
22,782.22%
Accolade  (ACCD)
2015-2021
4,692.73%
Semler Scientific (SMLR)
2015-2021
4,243.6%
P10 (PX)
2015-2021
3,814.65%
Five9 (FIVN)
2015-2021
2,958.35%
Atlanticus (ATLC)
2015-2021
2,811.02%
Gravity (GRVY)
2015-2021
2,743.07%
Cronos (CRON)
2015-2021
2,261.45%
Anavex Life Sciences (AVXL)
2015-2021
2,181.58%
Xpel (XPEL)
2015-2021
2,067.62%
BioLife Solutions (BLFS)
2015-2021
2,062.08%
Trupanion (TRUP)
2015-2021
1,807.95%
Digital Turbine (APPS)
2015-2021
1,737.05%
Astrana Health (ASTH)
2015-2021
1,649.52%
Quantum Computing  (QUBT)
2015-2021
1,320.83%
SolarEdge Technologies (SEDG)
2015-2021
1,302.85%
Kornit Digital (KRNT)
2015-2021
1,168.75%
Lithium Argentina (LAR)
2015-2021
1,139.48%
Centrus Energy (LEU)
2015-2021
1,077.12%
Ameresco (AMRC)
2015-2021
1,053.54%
Fulgent Genetics (FLGT)
2015-2021
992.18%
NAPCO Security Technologies (NSSC)
2015-2021
963.42%
Evotec SE ADR (EVO)
2015-2021
953.22%
Small-cap stocks are treated as having a market cap between $300M and $2B.