Immatics (IMTX) has had the highest return between 2018 and 2024 by a small-cap US stock, returning 136,900%.

ASSET	YEARS	% RETURN
Immatics (IMTX)	2018-2024	136,900%
Zhihu Inc ADR (ZH)	2018-2024	49,215.07%
Applied Digital (APLD)	2018-2024	22,150%
Innodata (INOD)	2018-2024	3,016.67%
Teekay Tankers (TNK)	2018-2024	2,854.71%
Xpel (XPEL)	2018-2024	2,741.96%
Perpetua Resources (PPTA)	2018-2024	2,463.41%
Atlanticus (ATLC)	2018-2024	2,295.83%
Quantum Computing (QUBT)	2018-2024	2,102.5%
Byrna Technologies (BYRN)	2018-2024	2,011.43%
Harrow Health (HROW)	2018-2024	1,912.94%
Centrus Energy (LEU)	2018-2024	1,582.62%
Sezzle Inc Common Stock (SEZL)	2018-2024	1,097.17%
P10 (PX)	2018-2024	1,067.68%
BlueLinx (BXC)	2018-2024	992.84%
Universal Technical Institute (UTI)	2018-2024	976.17%
Real Brokerage (REAX)	2018-2024	935.39%
Climb Global Solutions (CLMB)	2018-2024	819.5%
UFP Technologies (UFPT)	2018-2024	807.9%
CPI Card (PMTS)	2018-2024	790.22%
Turtle Beach (HEAR)	2018-2024	771.56%
NAPCO Security Technologies (NSSC)	2018-2024	754.85%
Acm Research (ACMR)	2018-2024	752%
Willis Lease Finance (WLFC)	2018-2024	743.14%
Semler Scientific (SMLR)	2018-2024	723.73%

Small-cap stocks are treated as having a market cap between $300M and $2B.