Dollar Tree (DLTR) had the highest return between 2008 and 2011 by a US stock in the S&P 500 (GSPC), returning 380.9%.

ASSET	YEARS	% RETURN
Dollar Tree (DLTR)	2008-2011	380.9%
Tractor Supply (TSCO)	2008-2011	318.71%
Booking (BKNG)	2008-2011	300.61%
Ross Stores (ROST)	2008-2011	290.92%
Ulta Beauty (ULTA)	2008-2011	281.88%
F5 Networks (FFIV)	2008-2011	278.73%
Edwards Lifesciences (EW)	2008-2011	209.26%
Estee Lauder Companies (EL)	2008-2011	171.38%
AutoZone (AZO)	2008-2011	170.58%
Old Dominion Freight Line (ODFL)	2008-2011	167.82%
Netflix (NFLX)	2008-2011	160.88%
Domino's Pizza Inc Common Stock (DPZ)	2008-2011	156.81%
Fortinet (FTNT)	2008-2011	156.59%
Transdigm (TDG)	2008-2011	150.5%
O’Reilly Automotive (ORLY)	2008-2011	147.68%
MarketAxess (MKTX)	2008-2011	145.13%
TJX Companies (TJX)	2008-2011	137.94%
Fastenal (FAST)	2008-2011	135.65%
Tyler Technologies (TYL)	2008-2011	134.5%
WW Grainger (GWW)	2008-2011	131.54%
Regeneron Pharmaceuticals (REGN)	2008-2011	130.77%
Chipotle Mexican Grill (CMG)	2008-2011	129.6%
Starbucks (SBUX)	2008-2011	128.45%
Ralph Lauren Corp Class A (RL)	2008-2011	128.12%
Generac (GNRC)	2008-2011	115.62%