Summit Therapeutics (SMMT) had the highest return in December 2022 by a US stock with a market cap of $2B+, returning 444.9%.

ASSET	MONTH	% RETURN
Summit Therapeutics (SMMT)	December 2022	444.87%
Madrigal Pharmaceuticals (MDGL)	December 2022	311%
Viking Therapeutics (VKTX)	December 2022	131.53%
Verona Pharma PLC ADR (VRNA)	December 2022	101.62%
Avidity Biosciences (RNA)	December 2022	90.47%
Wave Life Sciences (WVE)	December 2022	66.67%
Soleno Therapeutics (SLNO)	December 2022	59.68%
Arcellx (ACLX)	December 2022	55.44%
Alvotech (ALVO)	December 2022	53.85%
Bilibili (BILI)	December 2022	42.2%
Roivant Sciences (ROIV)	December 2022	38.96%
GDS (GDS)	December 2022	38.86%
Protagonist Therapeutics (PTGX)	December 2022	37.75%
Melco Resorts & Entertainment (MLCO)	December 2022	37.23%
SoundHound AI (SOUN)	December 2022	37.21%
NewAmsterdam Pharma Company NV Ordinary Shares (NAMS)	December 2022	37.11%
Immunovant (IMVT)	December 2022	35.29%
Global Business Travel (GBTG)	December 2022	35%
TG Therapeutics (TGTX)	December 2022	33.22%
Powell Industries (POWL)	December 2022	32.8%
360 DigiTech (QFIN)	December 2022	30.87%
Leonardo DRS, Inc Common Stock (DRS)	December 2022	30.67%
Samsara (IOT)	December 2022	30.16%
Smartsheet (SMAR)	December 2022	29.77%
MongoDB (MDB)	December 2022	27.88%