Celestica (CLS) has had the highest return between 2021 and 2024 by a large-cap US stock, returning 1,096.7%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2021-2024	1,096.69%
Super Micro Computer (SMCI)	2021-2024	979.56%
NVIDIA (NVDA)	2021-2024	972.67%
Permian Resources (PR)	2021-2024	910.21%
Grupo Financiero Galicia SA ADR (GGAL)	2021-2024	819.89%
YPF Sociedad Anonima (YPF)	2021-2024	785.92%
MicroStrategy (MSTR)	2021-2024	760.33%
Comfort Systems USA (FIX)	2021-2024	744.94%
Vistra Energy (VST)	2021-2024	707.17%
Fortress Transp & Infra Inv (FTAI)	2021-2024	663.43%
Targa Resources (TRGP)	2021-2024	629.12%
GameStop (GME)	2021-2024	555.58%
Sprouts Farmers Market LLC (SFM)	2021-2024	550.64%
Vertiv (VRT)	2021-2024	534.78%
Arista Networks (ANET)	2021-2024	530.9%
Constellation Energy (CEG)	2021-2024	521.9%
Broadcom (AVGO)	2021-2024	500.96%
Antero Resources (AR)	2021-2024	496.95%
Credo Technology (CRDO)	2021-2024	488.6%
Reddit (RDDT)	2021-2024	421.79%
Axon Enterprise (AXON)	2021-2024	413.17%
Texas Pacific Land Trust (TPL)	2021-2024	411.39%
EMCOR (EME)	2021-2024	410.97%
Eli Lilly and (LLY)	2021-2024	392.32%
Applovin (APP)	2021-2024	388.33%

Large-cap stocks are treated as having a market cap of $10B+.