XPO Logistics (XPO) had the highest return in April 2023 by a large-cap US stock, returning 39%.

ASSET	MONTH	% RETURN
XPO Logistics (XPO)	April 2023	39.02%
TKO (TKO)	April 2023	25.2%
Tenet Healthcare (THC)	April 2023	23.52%
Chipotle Mexican Grill (CMG)	April 2023	21.98%
Intuitive Surgical (ISRG)	April 2023	18.45%
BeOne Medicines (ONC)	April 2023	18.29%
Universal Health Services (UHS)	April 2023	18.13%
New Oriental Education & Technology (EDU)	April 2023	17.65%
Symbotic (SYM)	April 2023	17.52%
Smith & Nephew SNATS (SNN)	April 2023	17.25%
Baxter International (BAX)	April 2023	16.78%
Gold Fields Ltd ADR (GFI)	April 2023	16.73%
PulteGroup (PHM)	April 2023	15.72%
Eli Lilly and (LLY)	April 2023	15.33%
Facebook (META)	April 2023	15.07%
Molson Coors Brewing (TAP)	April 2023	14.8%
Intracellular Th (ITCI)	April 2023	14.71%
DraftKings (DKNG)	April 2023	14.59%
Insmed (INSM)	April 2023	14.37%
Koninklijke Philips NV ADR (PHG)	April 2023	14.1%
Teck Resources Ltd Class B (TECK)	April 2023	13.35%
Core & Main (CNM)	April 2023	13.3%
Petróleo Brasileiro SA - Petrobras (PBR.A)	April 2023	13.29%
Medtronic (MDT)	April 2023	13.19%
Rollins (ROL)	April 2023	13.18%

Large-cap stocks are treated as having a market cap of $10B+.