Celestica (CLS) has had the highest return between 2021 and 2024 by a large-cap US stock, returning 1,117.2%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2021-2024	1,117.18%
Super Micro Computer (SMCI)	2021-2024	1,046.23%
Permian Resources (PR)	2021-2024	963.07%
NVIDIA (NVDA)	2021-2024	927%
MicroStrategy (MSTR)	2021-2024	881.6%
YPF Sociedad Anonima (YPF)	2021-2024	822.57%
Comfort Systems USA (FIX)	2021-2024	794.27%
Vistra Energy (VST)	2021-2024	714.44%
Fortress Transp & Infra Inv (FTAI)	2021-2024	677.24%
Targa Resources (TRGP)	2021-2024	644.85%
Sprouts Farmers Market LLC (SFM)	2021-2024	631.63%
Vertiv (VRT)	2021-2024	572.42%
Constellation Energy (CEG)	2021-2024	547.02%
Credo Technology (CRDO)	2021-2024	527.69%
Arista Networks (ANET)	2021-2024	518.35%
GameStop (GME)	2021-2024	489.26%
Antero Resources (AR)	2021-2024	481.15%
Broadcom (AVGO)	2021-2024	462.14%
EMCOR (EME)	2021-2024	428.37%
Texas Pacific Land Trust (TPL)	2021-2024	428.02%
Axon Enterprise (AXON)	2021-2024	424.27%
Reddit (RDDT)	2021-2024	407.79%
Coca-Cola Consolidated (COKE)	2021-2024	394.5%
Eli Lilly and (LLY)	2021-2024	388.27%
Quanta Services (PWR)	2021-2024	379.71%

Large-cap stocks are treated as having a market cap of $10B+.