Clene (CLNN) had the highest return between 2010 and 2020 by a US stock, returning 18,033,233.3%.

ASSET	YEARS	% RETURN
Clene (CLNN)	2010-2020	18,033,233.33%
HIVE Blockchain Technologies (HIVE)	2010-2020	1,889,900%
Bragg Gaming (BRAG)	2010-2020	1,883,233.33%
Fresh2 (FRES)	2010-2020	1,882,670.87%
Crown Electrokinetics (CRKN)	2010-2020	1,299,900%
Scinai Immunotherapeutics (SCNI)	2010-2020	561,900%
Ryvyl (RVYL)	2010-2020	502,976.92%
Luokung Technology (LKCO)	2010-2020	391,266.91%
Immatics (IMTX)	2010-2020	215,700%
Xpel (XPEL)	2010-2020	135,584.21%
Scienture (SCNX)	2010-2020	65,986.23%
CEA Industries (CEAD)	2010-2020	41,900%
Alarum Technologies (ALAR)	2010-2020	41,787.91%
NAYA Biosciences (NAYA)	2010-2020	30,614.29%
Skye Bioscience, Inc Common Stock (SKYE)	2010-2020	24,900%
Avalon GloboCare (ALBT)	2010-2020	23,900%
Enveric Biosciences (ENVB)	2010-2020	20,809.86%
American Lithium Corp Common Stock (AMLI)	2010-2020	19,837.5%
Tesla (TSLA)	2010-2020	18,469.77%
Paysign (PAYS)	2010-2020	11,500%
Nocera (NCRA)	2010-2020	10,900%
Proficient Auto Logistics, Inc Common Stock (PAL)	2010-2020	10,858.9%
Wheels Up Experience (UP)	2010-2020	10,231.61%
SilverCrest Metals (SILV)	2010-2020	10,063.64%
Aurinia Pharmaceuticals (AUPH)	2010-2020	8,384.66%