Applovin (APP) has had the highest return between 2024 and 2025 by a large-cap US stock, returning 829.6%.

ASSET	YEARS	% RETURN
Applovin (APP)	2024-2025	829.56%
Summit Therapeutics (SMMT)	2024-2025	738.76%
Reddit (RDDT)	2024-2025	494.12%
Rocket Lab USA (RKLB)	2024-2025	429.72%
MicroStrategy (MSTR)	2024-2025	392.79%
Carvana (CVNA)	2024-2025	375.61%
Palantir Technologies Inc Class A Common Stock (PLTR)	2024-2025	370.56%
Grupo Financiero Galicia SA ADR (GGAL)	2024-2025	329.74%
Vistra Energy (VST)	2024-2025	309.44%
Robinhood Markets (HOOD)	2024-2025	301.49%
Celestica (CLS)	2024-2025	250.87%
Sprouts Farmers Market LLC (SFM)	2024-2025	223.42%
CAVA (CAVA)	2024-2025	218.95%
GE Vernova LLC (GEV)	2024-2025	207.4%
Flex (FLEX)	2024-2025	204.96%
Sea (SE)	2024-2025	204.8%
Carpenter Technology (CRS)	2024-2025	201.55%
Spotify Technology (SPOT)	2024-2025	186.54%
Ubiquiti Networks (UI)	2024-2025	182.51%
Natera (NTRA)	2024-2025	172.73%
United Airlines (UAL)	2024-2025	163.21%
Interactive Brokers (IBKR)	2024-2025	155.66%
Insmed (INSM)	2024-2025	153.25%
Constellation Energy (CEG)	2024-2025	152.51%
Axon Enterprise (AXON)	2024-2025	151.49%

Large-cap stocks are treated as having a market cap of $10B+.