YPF Sociedad Anonima (YPF) has had the highest return between 2022 and 2025 by a large-cap US stock, returning 939%.

ASSET	YEARS	% RETURN
YPF Sociedad Anonima (YPF)	2022-2025	938.96%
Celestica (CLS)	2022-2025	802.06%
Grupo Financiero Galicia SA ADR (GGAL)	2022-2025	773.96%
Summit Therapeutics (SMMT)	2022-2025	735.2%
Constellation Energy (CEG)	2022-2025	689.97%
Carpenter Technology (CRS)	2022-2025	643.22%
Vistra Energy (VST)	2022-2025	628.49%
Super Micro Computer (SMCI)	2022-2025	523.18%
MicroStrategy (MSTR)	2022-2025	519.77%
Reddit (RDDT)	2022-2025	494.12%
Sprouts Farmers Market LLC (SFM)	2022-2025	422.61%
TechnipFMC (FTI)	2022-2025	401.08%
Flex (FLEX)	2022-2025	395.78%
Fortress Transp & Infra Inv (FTAI)	2022-2025	349.92%
Vertiv (VRT)	2022-2025	339.96%
Comfort Systems USA (FIX)	2022-2025	334.89%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	334.42%
Fair Isaac (FICO)	2022-2025	325.53%
Targa Resources (TRGP)	2022-2025	315.67%
NVIDIA (NVDA)	2022-2025	315.58%
Axon Enterprise (AXON)	2022-2025	308.67%
Howmet Aerospace (HWM)	2022-2025	298.69%
MakeMyTrip (MMYT)	2022-2025	288.32%
Applovin (APP)	2022-2025	285.62%
SharkNinja (SN)	2022-2025	280.82%

Large-cap stocks are treated as having a market cap of $10B+.