Celestica (CLS) has had the highest return between 2021 and 2025 by a large-cap US stock, returning 1,133%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2021-2025	1,133.01%
Permian Resources (PR)	2021-2025	994.21%
Grupo Financiero Galicia SA ADR (GGAL)	2021-2025	869.67%
NVIDIA (NVDA)	2021-2025	846.36%
Super Micro Computer (SMCI)	2021-2025	774.21%
Vistra Energy (VST)	2021-2025	773.89%
YPF Sociedad Anonima (YPF)	2021-2025	728.16%
Comfort Systems USA (FIX)	2021-2025	724.77%
MicroStrategy (MSTR)	2021-2025	719.66%
Targa Resources (TRGP)	2021-2025	718.44%
Constellation Energy (CEG)	2021-2025	689.97%
Sprouts Farmers Market LLC (SFM)	2021-2025	667.87%
Carpenter Technology (CRS)	2021-2025	662.45%
Antero Resources (AR)	2021-2025	570.56%
Reddit (RDDT)	2021-2025	494.12%
Arista Networks (ANET)	2021-2025	493.42%
Vertiv (VRT)	2021-2025	490.52%
Fortress Transp & Infra Inv (FTAI)	2021-2025	483.15%
GameStop (GME)	2021-2025	479.16%
Texas Pacific Land Trust (TPL)	2021-2025	460.18%
Coca-Cola Consolidated (COKE)	2021-2025	428.19%
Applovin (APP)	2021-2025	423.34%
Axon Enterprise (AXON)	2021-2025	420.26%
Broadcom (AVGO)	2021-2025	417.39%
Flex (FLEX)	2021-2025	401.22%

Large-cap stocks are treated as having a market cap of $10B+.