MicroStrategy (MSTR) has had the highest return between 2020 and 2025 by a large-cap US stock, returning 2,289%.

ASSET	YEARS	% RETURN
MicroStrategy (MSTR)	2020-2025	2,289.04%
NVIDIA (NVDA)	2020-2025	1,981.16%
GameStop (GME)	2020-2025	1,692.18%
Tesla (TSLA)	2020-2025	1,274.91%
Summit Therapeutics (SMMT)	2020-2025	1,252.5%
Antero Resources (AR)	2020-2025	1,196.88%
Celestica (CLS)	2020-2025	1,109.27%
Super Micro Computer (SMCI)	2020-2025	1,065.62%
Vertiv (VRT)	2020-2025	896.77%
Futu (FUTU)	2020-2025	828.18%
Comfort Systems USA (FIX)	2020-2025	775.78%
Axon Enterprise (AXON)	2020-2025	764.59%
Arista Networks (ANET)	2020-2025	738.9%
Sprouts Farmers Market LLC (SFM)	2020-2025	699.95%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2025	697.6%
Crowdstrike (CRWD)	2020-2025	693.66%
Cloudflare (NET)	2020-2025	691.42%
Constellation Energy (CEG)	2020-2025	689.97%
Deckers Outdoor (DECK)	2020-2025	673.82%
Fortress Transp & Infra Inv (FTAI)	2020-2025	670.15%
Vistra Energy (VST)	2020-2025	666.37%
Broadcom (AVGO)	2020-2025	644.35%
Quanta Services (PWR)	2020-2025	634.18%
Flex (FLEX)	2020-2025	614.75%
Builders FirstSource (BLDR)	2020-2025	558.93%

Large-cap stocks are treated as having a market cap of $10B+.