Tectonic Therapeutic (TECX) has had the highest return between 2020 and 2024 by a US stock, returning 4,488,900%.

ASSET	YEARS	% RETURN
Tectonic Therapeutic (TECX)	2020-2024	4,488,900%
A2Z Smart Technologies (AZ)	2020-2024	1,070,733.33%
Cadrenal Therapeutics, Inc Common Stock (CVKD)	2020-2024	933,900%
MGO Global Inc Common Stock (MGOL)	2020-2024	469,900%
Gorilla Technology (GRRR)	2020-2024	434,900%
Asset Entities Inc Class B Common Stock (ASST)	2020-2024	208,066.67%
AppTech Payments Corp Warrant (APCXW)	2020-2024	199,700%
Jianzhi Education Technology Group Company Limited American Depositary Shares (JZ)	2020-2024	144,762.5%
authID (AUID)	2020-2024	105,212.5%
Zhihu Inc ADR (ZH)	2020-2024	48,804.11%
Digihost Technology (DGHI)	2020-2024	26,471.43%
Applied Blockchain (APLD)	2020-2024	21,080.56%
Ainos (AIMD)	2020-2024	11,017.5%
XORTX Therapeutics (XRTX)	2020-2024	10,900%
Agape ATP Corporation Common Stock (ATPC)	2020-2024	8,585.71%
Azitra (AZTR)	2020-2024	8,292.86%
SDCL EDGE Acquisition (SEDA.UN)	2020-2024	5,505%
Iteris (ITI)	2020-2024	5,500%
Digital Brands (DBGIW)	2020-2024	4,754.84%
ZyVersa Therapeutics (ZVSA)	2020-2024	3,956.94%
Innodata (INOD)	2020-2024	3,955.26%
Kaival Brands Innovations (KAVL)	2020-2024	3,916.5%
Bone Biologics Corp Warrants (BBLGW)	2020-2024	3,243.9%
CPI Card (PMTS)	2020-2024	3,074.44%
Alpha Metallurgical Resources (AMR)	2020-2024	2,843.07%