YPF Sociedad Anonima (YPF) has had the highest return between 2022 and 2025 by a large-cap US stock, returning 1,017.4%.

ASSET	YEARS	% RETURN
YPF Sociedad Anonima (YPF)	2022-2025	1,017.4%
Celestica (CLS)	2022-2025	1,006.55%
Summit Therapeutics (SMMT)	2022-2025	807.76%
Grupo Financiero Galicia SA ADR (GGAL)	2022-2025	805.65%
Constellation Energy (CEG)	2022-2025	799.8%
Vistra Energy (VST)	2022-2025	777.05%
Super Micro Computer (SMCI)	2022-2025	659.02%
Carpenter Technology (CRS)	2022-2025	636.05%
Credo Technology (CRDO)	2022-2025	606.61%
MicroStrategy (MSTR)	2022-2025	585.26%
Vertiv (VRT)	2022-2025	491.83%
Comfort Systems USA (FIX)	2022-2025	461.23%
Reddit (RDDT)	2022-2025	440.41%
Flex (FLEX)	2022-2025	431.01%
TechnipFMC (FTI)	2022-2025	429.3%
NVIDIA (NVDA)	2022-2025	394.06%
Sprouts Farmers Market LLC (SFM)	2022-2025	392.76%
Targa Resources (TRGP)	2022-2025	332.91%
Fair Isaac (FICO)	2022-2025	330.13%
EMCOR (EME)	2022-2025	324.74%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	318.68%
Howmet Aerospace (HWM)	2022-2025	299.8%
Axon Enterprise (AXON)	2022-2025	287.99%
Broadcom (AVGO)	2022-2025	286.78%
Applovin (APP)	2022-2025	280.76%

Large-cap stocks are treated as having a market cap of $10B+.