Helport AI Limited Ordinary Shares (HPAI) had the highest return between 2015 and 2021 by a US stock, returning 9,759,900%.

ASSET	YEARS	% RETURN
Helport AI Limited Ordinary Shares (HPAI)	2015-2021	9,759,900%
Ainos (AIMD)	2015-2021	1,105,163.16%
Faraday Future Intelligent Electric (FFIE)	2015-2021	529,143.52%
VERB TECHNOLOGY (VERB)	2015-2021	498,392.46%
Immatics (IMTX)	2015-2021	268,700%
Freedom (FRHC)	2015-2021	55,364%
Applied Digital (APLD)	2015-2021	43,095.88%
AquaBounty Technologies (AQB)	2015-2021	29,066.67%
Immunoprecise Antibodies (IPA)	2015-2021	27,387.18%
NAYA Biosciences (NAYA)	2015-2021	25,515.38%
eXp World (EXPI)	2015-2021	22,770.01%
Alarum Technologies (ALAR)	2015-2021	20,843.95%
Avalon GloboCare (ALBT)	2015-2021	17,471.43%
Metalla Royalty & Streaming (MTA)	2015-2021	14,890.22%
Celsius (CELH)	2015-2021	14,811.04%
HIVE Blockchain Technologies (HIVE)	2015-2021	12,471.43%
Kaival Brands Innovations (KAVL)	2015-2021	12,321.67%
SilverCrest Metals (SILV)	2015-2021	7,090.91%
Sangoma Technologies (SANG)	2015-2021	6,644%
NVIDIA (NVDA)	2015-2021	5,977.05%
Blackboxstocks (BLBX)	2015-2021	5,850%
Zynex (ZYXI)	2015-2021	5,586.5%
Advanced Micro Devices (AMD)	2015-2021	5,229.63%
Shopify (SHOP)	2015-2021	4,819.25%
Accolade (ACCD)	2015-2021	4,692.73%