Clene (CLNN) had the highest return in the 2010s by a US stock, returning 17,466,566.7%.

ASSET	DECADE	% RETURN
Clene (CLNN)	2010s	17,466,566.67%
Scinai Immunotherapeutics (SCNI)	2010s	1,857,900%
Luokung Technology (LKCO)	2010s	938,029.5%
Bragg Gaming (BRAG)	2010s	313,233.33%
Immatics (IMTX)	2010s	207,900%
Enveric Biosciences (ENVB)	2010s	127,619.69%
Alarum Technologies (ALAR)	2010s	89,280.53%
CEA Industries (CEAD)	2010s	83,900%
Skye Bioscience, Inc Common Stock (SKYE)	2010s	81,775%
HIVE Blockchain Technologies (HIVE)	2010s	69,900%
Ryvyl (RVYL)	2010s	46,053.85%
Avalon GloboCare (ALBT)	2010s	41,257.14%
Xpel (XPEL)	2010s	38,452.63%
Paysign (PAYS)	2010s	25,275%
Scienture (SCNX)	2010s	13,641.98%
Aurinia Pharmaceuticals (AUPH)	2010s	12,329.45%
Proficient Auto Logistics, Inc Common Stock (PAL)	2010s	10,858.9%
Nocera (NCRA)	2010s	9,900%
Blackboxstocks (BLBX)	2010s	8,150%
SilverCrest Metals (SILV)	2010s	6,027.27%
Natural Health Trend (NHTC)	2010s	5,026.16%
Salarius Pharmaceuticals (SLRX)	2010s	4,625%
Cronos (CRON)	2010s	4,520.48%
Caesars Entertainment (CZR)	2010s	4,487.69%
CoreCard (CCRD)	2010s	4,437.09%