MicroStrategy (MSTR) has had the highest return between 2020 and 2025 by a US stock with a market cap of $10B+, returning 2,553.9%.

ASSET	YEARS	% RETURN
MicroStrategy (MSTR)	2020-2025	2,553.95%
NVIDIA (NVDA)	2020-2025	2,413.84%
GameStop (GME)	2020-2025	2,038.11%
Super Micro Computer (SMCI)	2020-2025	1,428.3%
Tesla (TSLA)	2020-2025	1,352.47%
Antero Resources (AR)	2020-2025	1,150.35%
Fortress Transp & Infra Inv (FTAI)	2020-2025	1,130.97%
Vertiv (VRT)	2020-2025	1,109.91%
Celestica (CLS)	2020-2025	1,088.45%
Summit Therapeutics (SMMT)	2020-2025	991.88%
Comfort Systems USA (FIX)	2020-2025	836.64%
Arista Networks (ANET)	2020-2025	825.55%
Broadcom (AVGO)	2020-2025	752.79%
Vistra Energy (VST)	2020-2025	709.53%
Quanta Services (PWR)	2020-2025	708.78%
Futu (FUTU)	2020-2025	671.35%
Axon Enterprise (AXON)	2020-2025	671.02%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2025	659.2%
Deckers Outdoor (DECK)	2020-2025	636.95%
Crowdstrike (CRWD)	2020-2025	632.28%
Sprouts Farmers Market LLC (SFM)	2020-2025	625.94%
Constellation Energy (CEG)	2020-2025	615.25%
Flex (FLEX)	2020-2025	597.19%
Cloudflare (NET)	2020-2025	561.19%
Credo Technology (CRDO)	2020-2025	533.39%