Summit Therapeutics (SMMT) had the highest return in December 2022 by a large-cap US stock, returning 444.9%.

ASSET	MONTH	% RETURN
Summit Therapeutics (SMMT)	December 2022	444.87%
Samsara (IOT)	December 2022	30.16%
MongoDB (MDB)	December 2022	27.88%
New Oriental Education & Technology (EDU)	December 2022	25.84%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	December 2022	22.61%
Tencent Music Entertainment (TME)	December 2022	20.7%
Mobileye Global Inc Class A Common Stock (MBLY)	December 2022	20.27%
Grupo Financiero Galicia SA ADR (GGAL)	December 2022	19.53%
DocuSign (DOCU)	December 2022	18.75%
Sumitomo Mitsui Financial (SMFG)	December 2022	17.94%
Mizuho Financial (MFG)	December 2022	16.39%
BeiGene (BGNE)	December 2022	15.47%
Haleon (HLN)	December 2022	14.29%
Ciena (CIEN)	December 2022	13.04%
Joint Stock Company Kaspikz American Depository Shares (KSPI)	December 2022	12.82%
Monday (MNDY)	December 2022	11.93%
Trip Group Ltd ADR (TCOM)	December 2022	11.91%
Huazhu (HTHT)	December 2022	11.43%
Okta (OKTA)	December 2022	10.29%
EXACT Sciences (EXAS)	December 2022	10.02%
ZTO Express (Cayman) (ZTO)	December 2022	9.63%
Banco De Chile (BCH)	December 2022	9.52%
YPF Sociedad Anonima (YPF)	December 2022	9.02%
Deutsche Bank (DB)	December 2022	8.68%
Molson Coors Beverage (TAP.A)	December 2022	8.45%

Large-cap stocks are treated as having a market cap of $10B+.