Tempest Therapeutics (TPST) had the highest return in Q4 2023 by a US stock, returning 1,319.4%.

ASSET	QUARTER	% RETURN
Tempest Therapeutics (TPST)	Q4 2023	1,319.35%
Regis Corporation Common Stock (RGS)	Q4 2023	1,219.65%
JIN MEDICAL INTERNATIONAL LTD Ordinary Shares (ZJYL)	Q4 2023	941.35%
Binah Capital Group, Inc Warrants (BCGWW)	Q4 2023	693.65%
Cardio Diagnostics (CDIO)	Q4 2023	632.35%
Direct Digital (DRCT)	Q4 2023	483.53%
QXO (QXO)	Q4 2023	416.92%
Mawson Infrastructure (MIGI)	Q4 2023	401.65%
Nkarta (NKTX)	Q4 2023	371.43%
Myomo (MYO)	Q4 2023	351.35%
Shattuck Labs (STTK)	Q4 2023	348.43%
Cardio Diagnostics (CDIOW)	Q4 2023	339.14%
Altimmune (ALT)	Q4 2023	326.14%
Cipher Mining (CIFRW)	Q4 2023	311.9%
Lixiang Education (LXEH)	Q4 2023	307.41%
Porch (PRCH)	Q4 2023	294.87%
Incannex Healthcare Ltd ADR (IXHL)	Q4 2023	289.92%
Sky Harbour Group Corporation WT (SKYH.WT)	Q4 2023	284.62%
E-Home Household Service (EJH)	Q4 2023	266.97%
Gyre Therapeutics (GYRE)	Q4 2023	249.52%
Argo Blockchain PLC ADR (ARBK)	Q4 2023	243.12%
Ekso Bionics (EKSO)	Q4 2023	238.75%
Absci (ABSI)	Q4 2023	218.18%
Alpha Technology Group Limited Ordinary Shares (ATGL)	Q4 2023	217.5%
Sera Prognostics (SERA)	Q4 2023	213.09%