Monster Beverage (MNST) had the highest return between 2000 and 2008 by a US stock in the S&P 500 (GSPC), returning 6,165%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2000-2008	6,165.02%
Deckers Outdoor (DECK)	2000-2008	2,943.35%
Gilead Sciences (GILD)	2000-2008	1,332.29%
DaVita HealthCare Partners (DVA)	2000-2008	1,001.56%
ANSYS (ANSS)	2000-2008	925.37%
NVR (NVR)	2000-2008	855.5%
Axon Enterprise (AXON)	2000-2008	805.19%
Tractor Supply (TSCO)	2000-2008	800.06%
Hologic (HOLX)	2000-2008	799.39%
Old Dominion Freight Line (ODFL)	2000-2008	793.29%
BlackRock (BLK)	2000-2008	736.1%
Tapestry (TPR)	2000-2008	730.77%
EOG Resources (EOG)	2000-2008	704.6%
JB Hunt Transport Services (JBHT)	2000-2008	682.01%
W R Berkley (WRB)	2000-2008	681.82%
Occidental Petroleum (OXY)	2000-2008	610.89%
Intuitive Surgical (ISRG)	2000-2008	605.54%
CarMax (KMX)	2000-2008	600.44%
Quest Diagnostics (DGX)	2000-2008	599.18%
Laboratory Corporation of America (LH)	2000-2008	598.62%
CH Robinson Worldwide (CHRW)	2000-2008	507.87%
Jacobs Solutions (J)	2000-2008	490.87%
CME (CME)	2000-2008	468.86%
First Solar (FSLR)	2000-2008	463.1%
Arch Capital (ACGL)	2000-2008	452.52%