Constellation Energy (CEG) has had the highest return between 2022 and 2025 by a US stock in the S&P 500 (GSPC), returning 738.4%.

ASSET	YEARS	% RETURN
Constellation Energy (CEG)	2022-2025	738.42%
Super Micro Computer (SMCI)	2022-2025	713.27%
Vistra Energy (VST)	2022-2025	683.36%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	503.76%
NVIDIA (NVDA)	2022-2025	336.18%
Axon Enterprise (AXON)	2022-2025	333.74%
Fair Isaac (FICO)	2022-2025	325.22%
Targa Resources (TRGP)	2022-2025	314.24%
Howmet Aerospace (HWM)	2022-2025	302.92%
Broadcom (AVGO)	2022-2025	261.03%
GE Aerospace (GE)	2022-2025	250.87%
Royal Caribbean Cruises (RCL)	2022-2025	242.48%
Texas Pacific Land Trust (TPL)	2022-2025	242.41%
Eli Lilly and (LLY)	2022-2025	229.74%
GE Vernova LLC (GEV)	2022-2025	228.92%
Arista Networks (ANET)	2022-2025	228.88%
Deckers Outdoor (DECK)	2022-2025	174.87%
Quanta Services (PWR)	2022-2025	173.55%
Cardinal Health (CAH)	2022-2025	165.9%
NRG Energy (NRG)	2022-2025	164.58%
Progressive (PGR)	2022-2025	152.57%
Godaddy (GDDY)	2022-2025	150%
Marathon Petroleum (MPC)	2022-2025	149.62%
Williams Companies (WMB)	2022-2025	148.49%
Boston Scientific (BSX)	2022-2025	147.12%