Know Labs (KNW) had the highest return between 2000 and 2012 by a US stock, returning 1,373,877.1%.

ASSET	YEARS	% RETURN
Know Labs (KNW)	2000-2012	1,373,877.1%
Perspective Therapeutics (CATX)	2000-2012	259,900%
Aris Mining (ARMN)	2000-2012	52,857.06%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2000-2012	30,163.16%
Monster Beverage (MNST)	2000-2012	19,645.96%
Pioneer Power Solutions (PPSI)	2000-2012	11,111.15%
BRF SA ADR (BRFS)	2000-2012	9,792.47%
Clean Harbors (CLH)	2000-2012	8,926.91%
HF Sinclair (DINO)	2000-2012	7,779.18%
MEDIFAST (MED)	2000-2012	7,577.56%
Intellinetics (INLX)	2000-2012	6,899.99%
Gulf Resources (GURE)	2000-2012	5,700%
American Vanguard (AVD)	2000-2012	5,550.34%
Companhia Siderurgica Nacional ADR (SID)	2000-2012	5,329.71%
Banco Bradesco SA ADR (BBD)	2000-2012	4,892.4%
Altria (MO)	2000-2012	4,806.82%
Middleby (MIDD)	2000-2012	4,656.45%
Deckers Outdoor (DECK)	2000-2012	4,503.36%
Tractor Supply (TSCO)	2000-2012	4,440.18%
Ambev SA ADR (ABEV)	2000-2012	4,335.39%
Cocrystal Pharma (COCP)	2000-2012	4,233.33%
Team (TISI)	2000-2012	3,957.6%
BP Prudhoe Bay Royalty Trust (BPT)	2000-2012	3,747.59%
DXP Enterprises (DXPE)	2000-2012	3,638.67%
CEA Industries (CEAD)	2000-2012	3,266.67%