Hirequest (HQI) had the highest return between 2000 and 2005 by a US stock, returning 44,469,800%.

ASSET	YEARS	% RETURN
Hirequest (HQI)	2000-2005	44,469,800%
Flotek Industries (FTK)	2000-2005	18,649,900%
Perspective Therapeutics (CATX)	2000-2005	2,416,566.67%
Opus Genetics (IRD)	2000-2005	959,900%
Supercom (SPCB)	2000-2005	139,901.12%
Alaunos Therapeutics (TCRT)	2000-2005	120,270.37%
Hudbay Minerals (HBM)	2000-2005	25,011.96%
Frontline (FRO)	2000-2005	9,679.96%
Xcel Brands (XELB)	2000-2005	9,399.96%
Portage Biotech (PRTG)	2000-2005	8,956.6%
TherapeuticsMD (TXMD)	2000-2005	7,400.01%
Houston American Energy (HUSA)	2000-2005	6,200.4%
Dmc Global (BOOM)	2000-2005	4,728.89%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2000-2005	4,575%
CBAK Energy Technology (CBAT)	2000-2005	4,320%
Monster Beverage (MNST)	2000-2005	3,581.39%
Protalix Biotherapeutics (PLX)	2000-2005	3,300%
Broadwind Energy (BWEN)	2000-2005	3,260.13%
Amedisys (AMED)	2000-2005	2,972.15%
American Vanguard (AVD)	2000-2005	2,953.22%
Gulf Resources (GURE)	2000-2005	2,900%
Denison Mines (DNN)	2000-2005	2,685.85%
Oramed Pharmaceuticals (ORMP)	2000-2005	2,470.84%
BRF SA ADR (BRFS)	2000-2005	2,338.81%
Clean Harbors (CLH)	2000-2005	2,263.8%