Know Labs (KNW) had the highest return between 1999 and 2010 by a US stock, returning 4,885,152.2%.

ASSET	YEARS	% RETURN
Know Labs (KNW)	1999-2010	4,885,152.16%
Perspective Therapeutics (CATX)	1999-2010	376,566.67%
Aris Mining (ARMN)	1999-2010	326,443.75%
Houston American Energy (HUSA)	1999-2010	37,506.02%
Pioneer Power Solutions (PPSI)	1999-2010	29,429.23%
Companhia Siderurgica Nacional ADR (SID)	1999-2010	24,060%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	1999-2010	21,400%
Frontline (FRO)	1999-2010	18,508.35%
BP Prudhoe Bay Royalty Trust (BPT)	1999-2010	11,880.26%
Deckers Outdoor (DECK)	1999-2010	11,153.18%
Ainos (AIMD)	1999-2010	9,001.8%
China Yuchai International (CYD)	1999-2010	8,189.57%
Monster Beverage (MNST)	1999-2010	7,693.74%
BRF SA ADR (BRFS)	1999-2010	7,599.85%
Gerdau SA ADR (GGB)	1999-2010	6,650.36%
BTCS (BTCS)	1999-2010	5,920%
Southern Copper (SCCO)	1999-2010	5,882.81%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2010	5,643.77%
McEwen Mining (MUX)	1999-2010	5,279.81%
Banco Bradesco SA ADR (BBD)	1999-2010	5,153.95%
Clean Harbors (CLH)	1999-2010	5,074.15%
Suzano Papel e Celulose SA ADR (SUZ)	1999-2010	4,851.18%
Ambev SA ADR (ABEV)	1999-2010	4,652.9%
Denison Mines (DNN)	1999-2010	4,588.94%
Middleby (MIDD)	1999-2010	4,255.36%