Clene (CLNN) had the highest return between 2016 and 2021 by a US stock, returning 6,833,233.3%.

ASSET	YEARS	% RETURN
Clene (CLNN)	2016-2021	6,833,233.33%
Crown Electrokinetics (CRKN)	2016-2021	3,989,900%
XORTX Therapeutics (XRTX)	2016-2021	1,044,239.62%
Zhihu Inc ADR (ZH)	2016-2021	455,242.47%
Fresh2 (FRES)	2016-2021	433,292.54%
Luokung Technology (LKCO)	2016-2021	348,101.44%
Immatics (IMTX)	2016-2021	268,700%
authID (AUID)	2016-2021	223,041.15%
KWESST Micro Systems Inc Common Stock (KWE)	2016-2021	86,695.35%
Connexa Sports Technologies (YYAI)	2016-2021	68,700%
Bragg Gaming (BRAG)	2016-2021	53,986.02%
Freedom (FRHC)	2016-2021	46,493.33%
Ainos (AIMD)	2016-2021	37,400%
Immunoprecise Antibodies (IPA)	2016-2021	35,633.33%
Applied Digital (APLD)	2016-2021	32,130.77%
Metalla Royalty & Streaming (MTA)	2016-2021	21,943.09%
Alarum Technologies (ALAR)	2016-2021	20,843.95%
Avalon GloboCare (ALBT)	2016-2021	17,471.43%
HIVE Blockchain Technologies (HIVE)	2016-2021	13,100%
Kaival Brands Innovations (KAVL)	2016-2021	10,247.22%
NAYA Biosciences (NAYA)	2016-2021	9,421.09%
Sangoma Technologies (SANG)	2016-2021	8,330%
Draganfly (DPRO)	2016-2021	8,309%
eXp World (EXPI)	2016-2021	7,934.34%
Castellum (CTM)	2016-2021	7,073.91%