XTI Aerospace (XTIA) had the highest return between 2012 and 2016 by a US stock, returning 243,902,339%.

ASSET	YEARS	% RETURN
XTI Aerospace (XTIA)	2012-2016	243,902,339%
iCoreConnect Inc Common stock (ICCT)	2012-2016	42,553,090%
Enveric Biosciences (ENVB)	2012-2016	6,975,896.57%
Scinai Immunotherapeutics (SCNI)	2012-2016	669,900%
Scienture (SCNX)	2012-2016	613,971.43%
Versus Systems Inc. (VS)	2012-2016	245,508.86%
Skye Bioscience, Inc Common Stock (SKYE)	2012-2016	188,650%
Salarius Pharmaceuticals (SLRX)	2012-2016	164,900%
QXO (QXO)	2012-2016	154,962.92%
Nutex Health (NUTX)	2012-2016	69,900%
American Lithium Corp Common Stock (AMLI)	2012-2016	51,566.67%
Nixxy (NIXX)	2012-2016	23,900%
CEA Industries (CEAD)	2012-2016	17,900%
Proficient Auto Logistics, Inc Common Stock (PAL)	2012-2016	17,437.31%
Blackboxstocks (BLBX)	2012-2016	17,400%
Vivakor (VIVK)	2012-2016	8,300%
Bragg Gaming (BRAG)	2012-2016	5,250%
Creative Medical Technology (CELZ)	2012-2016	4,536.36%
Natural Health Trend (NHTC)	2012-2016	3,845.99%
INVO Bioscience (INVO)	2012-2016	3,081.82%
NAYA Biosciences (NAYA)	2012-2016	3,081.82%
Arena (AREN)	2012-2016	2,792.2%
ACADIA Pharmaceuticals (ACAD)	2012-2016	2,521.82%
Par Pacific (PARR)	2012-2016	2,441.96%
Genmab A-S (GMAB)	2012-2016	2,435.57%