Summit Therapeutics (SMMT) has had the highest return between 2024 and 2025 by a US stock with a market cap of $5B+, returning 853.9%.

ASSET	YEARS	% RETURN
Summit Therapeutics (SMMT)	2024-2025	853.88%
Applovin (APP)	2024-2025	504.47%
Palantir Technologies Inc Class A Common Stock (PLTR)	2024-2025	453.27%
ADMA Biologics (ADMA)	2024-2025	373.56%
MicroStrategy (MSTR)	2024-2025	358.06%
Carvana (CVNA)	2024-2025	309.63%
Ast Spacemobile (ASTS)	2024-2025	299.15%
Grupo Financiero Galicia SA ADR (GGAL)	2024-2025	289.33%
Banco Macro SA B ADR (BMA)	2024-2025	262.84%
Rocket Lab USA (RKLB)	2024-2025	262.2%
Brinker International (EAT)	2024-2025	257.86%
Sprouts Farmers Market LLC (SFM)	2024-2025	233.92%
Robinhood Markets (HOOD)	2024-2025	223.23%
Hims Hers Health (HIMS)	2024-2025	209.43%
Verona Pharma PLC ADR (VRNA)	2024-2025	206.88%
Spotify Technology (SPOT)	2024-2025	205.37%
Vistra Energy (VST)	2024-2025	205%
Loar (LOAR)	2024-2025	203.82%
Sea (SE)	2024-2025	202.43%
Celestica (CLS)	2024-2025	193.44%
Harmony Gold Mining (HMY)	2024-2025	185.07%
Reddit (RDDT)	2024-2025	182.82%
GE Vernova LLC (GEV)	2024-2025	181.77%
Corcept Therapeutics (CORT)	2024-2025	181.5%
Texas Pacific Land Trust (TPL)	2024-2025	151.04%