ADMA Biologics (ADMA) has had the highest return between 2022 and 2025 by a US stock with a market cap of $3B+, returning 1,314.3%.

ASSET	YEARS	% RETURN
ADMA Biologics (ADMA)	2022-2025	1,314.29%
Verona Pharma PLC ADR (VRNA)	2022-2025	883.95%
YPF Sociedad Anonima (YPF)	2022-2025	848.83%
Super Micro Computer (SMCI)	2022-2025	844.86%
Vista Oil Gas ADR (VIST)	2022-2025	786.98%
Modine Manufacturing (MOD)	2022-2025	765.79%
Celestica (CLS)	2022-2025	761.31%
BBVA Banco Frances SA ADR (BBAR)	2022-2025	707.09%
Banco Macro SA B ADR (BMA)	2022-2025	663.42%
Summit Therapeutics (SMMT)	2022-2025	662.25%
Grupo Financiero Galicia SA ADR (GGAL)	2022-2025	648.45%
Carpenter Technology (CRS)	2022-2025	553.3%
Viking Therapeutics (VKTX)	2022-2025	519.91%
Transportadora de Gas del Sur SA ADR (TGS)	2022-2025	516.55%
Vistra Energy (VST)	2022-2025	513.95%
Constellation Energy (CEG)	2022-2025	503.25%
MicroStrategy (MSTR)	2022-2025	452.11%
Hims Hers Health (HIMS)	2022-2025	428.12%
Rhythm Pharmaceuticals (RYTM)	2022-2025	420.4%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	395.42%
Fortress Transp & Infra Inv (FTAI)	2022-2025	389.62%
TechnipFMC (FTI)	2022-2025	388.33%
Sprouts Farmers Market LLC (SFM)	2022-2025	379.75%
Sterling Construction (STRL)	2022-2025	376.95%
Flex (FLEX)	2022-2025	334.75%