Palantir Technologies Inc Class A Common Stock (PLTR) has had the highest return between 2022 and 2025 by a US stock with a market cap of $120B+, returning 410.8%.

ASSET	YEARS	% RETURN
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2025	410.78%
NVIDIA (NVDA)	2022-2025	240.97%
Eli Lilly and (LLY)	2022-2025	215.89%
GE Aerospace (GE)	2022-2025	211.3%
Broadcom (AVGO)	2022-2025	175.36%
Progressive (PGR)	2022-2025	167.63%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2022-2025	136.88%
T-Mobile US (TMUS)	2022-2025	131.48%
Vertex Pharmaceuticals (VRTX)	2022-2025	123.97%
Boston Scientific (BSX)	2022-2025	123.34%
HSBC Holdings PLC ADR (HSBC)	2022-2025	114.45%
International Business Machines (IBM)	2022-2025	104.69%
Walmart (WMT)	2022-2025	103.23%
Philip Morris International (PM)	2022-2025	102.81%
Exxon Mobil (XOM)	2022-2025	95.9%
SAP SE ADR (SAP)	2022-2025	94.37%
Booking (BKNG)	2022-2025	90.81%
Costco Wholesale (COST)	2022-2025	83.86%
AT&T (T)	2022-2025	79.58%
Uber Technologies (UBER)	2022-2025	77.12%
TJX Companies (TJX)	2022-2025	76.94%
Berkshire Hathaway (BRK.B)	2022-2025	72.68%
Berkshire Hathaway (BRK.A)	2022-2025	72.31%
Shell PLC ADR (SHEL)	2022-2025	67.58%
Gilead Sciences (GILD)	2022-2025	64.66%