Diginex Limited Ordinary Shares (DGNX) has had the highest return between 2022 and 2025 by a US stock with a market cap of $1B+, returning 2,482.2%.

ASSET	YEARS	% RETURN
Diginex Limited Ordinary Shares (DGNX)	2022-2025	2,482.16%
ADMA Biologics (ADMA)	2022-2025	1,314.29%
Sezzle Inc Common Stock (SEZL)	2022-2025	941.63%
Verona Pharma PLC ADR (VRNA)	2022-2025	883.95%
YPF Sociedad Anonima (YPF)	2022-2025	848.83%
Super Micro Computer (SMCI)	2022-2025	844.86%
Vista Oil Gas ADR (VIST)	2022-2025	786.98%
Modine Manufacturing (MOD)	2022-2025	765.79%
Celestica (CLS)	2022-2025	761.31%
BBVA Banco Frances SA ADR (BBAR)	2022-2025	707.09%
Soleno Therapeutics (SLNO)	2022-2025	670.35%
Banco Macro SA B ADR (BMA)	2022-2025	663.42%
Summit Therapeutics (SMMT)	2022-2025	662.25%
Grupo Supervielle (SUPV)	2022-2025	655.77%
Grupo Financiero Galicia SA ADR (GGAL)	2022-2025	648.45%
Innodata (INOD)	2022-2025	607.61%
Powell Industries (POWL)	2022-2025	566.64%
Carpenter Technology (CRS)	2022-2025	553.3%
Viking Therapeutics (VKTX)	2022-2025	519.91%
Transportadora de Gas del Sur SA ADR (TGS)	2022-2025	516.55%
Vistra Energy (VST)	2022-2025	513.95%
Constellation Energy (CEG)	2022-2025	503.25%
Empresa Distribuidora y Comercializadora Norte SA ADR (EDN)	2022-2025	495.14%
MicroStrategy (MSTR)	2022-2025	452.11%
Belite Bio Inc ADR (BLTE)	2022-2025	438.24%