Azitra (AZTR) has had the highest return between 2021 and 2025 by a US stock with a market cap of $1+, returning 5,275%.

ASSET	YEARS	% RETURN
Azitra (AZTR)	2021-2025	5,275%
Applied Digital (APLD)	2021-2025	2,797.78%
Vista Oil Gas ADR (VIST)	2021-2025	1,933.59%
Kolibri Global Energy Inc Common stock (KGEI)	2021-2025	1,795%
Zivo Bioscience (ZIVO)	2021-2025	1,764.04%
TSS, Inc Common Stock (TSSI)	2021-2025	1,657.24%
Alpha Metallurgical Resources (AMR)	2021-2025	1,612.64%
Consol Energy (CEIX)	2021-2025	1,420.8%
Power Solutions International, Inc Common Stock (PSIX)	2021-2025	1,106.19%
Energy Services Of America (ESOA)	2021-2025	1,095.64%
Tecnoglass (TGLS)	2021-2025	1,071.13%
Build-A-Bear Workshop (BBW)	2021-2025	1,066.15%
Celestica (CLS)	2021-2025	1,059.26%
Weatherford International (WFRD)	2021-2025	1,021.28%
Destination XL (DXLG)	2021-2025	1,003.05%
Permian Resources (PR)	2021-2025	977.56%
Sezzle Inc Common Stock (SEZL)	2021-2025	941.02%
Natural Resource Partners (NRP)	2021-2025	940.67%
NVIDIA (NVDA)	2021-2025	886.83%
Nano Nuclear Energy Inc Common Stock (NNE)	2021-2025	866.39%
RCM Technologies (RCMT)	2021-2025	861.08%
Grupo Financiero Galicia SA ADR (GGAL)	2021-2025	834.5%
CVR Partners (UAN)	2021-2025	827.63%
Dillards (DDS)	2021-2025	816.97%
Indivior PLC Ordinary Shares (INDV)	2021-2025	798.53%