MicroStrategy (MSTR) has had the highest return between 2020 and 2024 by a US stock with a market cap of $10B+, returning 2,724.5%.

ASSET	YEARS	% RETURN
MicroStrategy (MSTR)	2020-2024	2,724.49%
NVIDIA (NVDA)	2020-2024	2,188.28%
GameStop (GME)	2020-2024	1,832.9%
Super Micro Computer (SMCI)	2020-2024	1,510.48%
Fortress Transp & Infra Inv (FTAI)	2020-2024	1,211.23%
Summit Therapeutics (SMMT)	2020-2024	1,099.38%
Tesla (TSLA)	2020-2024	1,096.43%
Vertiv (VRT)	2020-2024	1,091.05%
Antero Resources (AR)	2020-2024	1,053.82%
Celestica (CLS)	2020-2024	930.08%
Comfort Systems USA (FIX)	2020-2024	916.85%
Quanta Services (PWR)	2020-2024	745.14%
Axon Enterprise (AXON)	2020-2024	736.26%
Futu (FUTU)	2020-2024	702.29%
Arista Networks (ANET)	2020-2024	677.36%
Sprouts Farmers Market LLC (SFM)	2020-2024	663.18%
Vistra Energy (VST)	2020-2024	659.83%
Builders FirstSource (BLDR)	2020-2024	638.69%
Crowdstrike (CRWD)	2020-2024	626.92%
Flex (FLEX)	2020-2024	607.18%
Carrier Global (CARR)	2020-2024	598.27%
Deckers Outdoor (DECK)	2020-2024	594.6%
Texas Pacific Land Trust (TPL)	2020-2024	580.79%
Constellation Energy (CEG)	2020-2024	573.71%
Cameco (CCJ)	2020-2024	562.43%