Genmab A-S (GMAB) had the highest return between 2012 and 2017 by a US stock with a market cap of $8B+, returning 2,434.6%.

ASSET	YEARS	% RETURN
Genmab A-S (GMAB)	2012-2017	2,434.56%
Netflix (NFLX)	2012-2017	1,811.95%
Alnylam Pharmaceuticals (ALNY)	2012-2017	1,425.21%
NVIDIA (NVDA)	2012-2017	1,359.47%
Sarepta Therapeutics (SRPT)	2012-2017	1,128.26%
Texas Pacific Land Trust (TPL)	2012-2017	1,046.24%
Constellation Brands Inc Class A (STZ)	2012-2017	1,021.22%
Grupo Financiero Galicia SA ADR (GGAL)	2012-2017	1,000.68%
Tesla (TSLA)	2012-2017	975.87%
Repligen (RGEN)	2012-2017	948.55%
Huazhu (HTHT)	2012-2017	944.57%
Builders FirstSource (BLDR)	2012-2017	937.62%
American Airlines (AAL)	2012-2017	934.47%
Insmed (INSM)	2012-2017	899.36%
Broadcom (AVGO)	2012-2017	864.36%
Align Technology (ALGN)	2012-2017	816.63%
Skechers (SKX)	2012-2017	811.08%
Western Alliance Bancorporation (WAL)	2012-2017	793.07%
Neurocrine Biosciences (NBIX)	2012-2017	787.76%
NetEase (NTES)	2012-2017	739.12%
Saia (SAIA)	2012-2017	720.77%
Monolithic Power Systems (MPWR)	2012-2017	695.66%
Take-Two Interactive Software (TTWO)	2012-2017	693.78%
Southwest Airlines (LUV)	2012-2017	684.26%
EPAM Systems (EPAM)	2012-2017	681.31%