Know Labs (KNW) had the highest return between 2004 and 2008 by a US stock, returning 534,224.4%.

ASSET	YEARS	% RETURN
Know Labs (KNW)	2004-2008	534,224.43%
Perspective Therapeutics (CATX)	2004-2008	66,566.67%
Ainos (AIMD)	2004-2008	19,616.98%
Gulf Resources (GURE)	2004-2008	5,900%
Universal Insurance (UVE)	2004-2008	5,698.94%
Broadwind Energy (BWEN)	2004-2008	5,300.22%
Champions Oncology (CSBR)	2004-2008	5,300%
Oramed Pharmaceuticals (ORMP)	2004-2008	3,134.28%
Monster Beverage (MNST)	2004-2008	3,078.84%
Insteel Industries (IIIN)	2004-2008	2,995.76%
Frontline (FRO)	2004-2008	2,591.24%
Ammo (POWW)	2004-2008	2,400%
CervoMed (CRVO)	2004-2008	2,122.22%
TOMI Environmental Solutions (TOMZ)	2004-2008	1,650%
MiMedx (MDXG)	2004-2008	1,323.03%
Dmc Global (BOOM)	2004-2008	1,284.74%
Sanara Medtech (SMTI)	2004-2008	1,140.74%
NeoGenomics (NEO)	2004-2008	1,120%
BRF SA ADR (BRFS)	2004-2008	1,102.26%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	2004-2008	1,093.13%
International Tower Hill Mines (THM)	2004-2008	1,063.44%
LifeMD (LFMD)	2004-2008	1,017.65%
Diamond Hill Investment (DHIL)	2004-2008	1,009.51%
Taoping (TAOP)	2004-2008	966.67%
VirnetX (VHC)	2004-2008	886.67%