Ainos (AIMD) had the highest return between 2020 and 2021 by a US stock, returning 1,574,900%.

ASSET	YEARS	% RETURN
Ainos (AIMD)	2020-2021	1,574,900%
Fresh2 (FRES)	2020-2021	433,292.54%
Applied Digital (APLD)	2020-2021	58,094.44%
NAYA Biosciences (NAYA)	2020-2021	31,614.29%
Accolade (ACCD)	2020-2021	4,692.73%
Firefly Neuroscience (AIFF)	2020-2021	3,707.69%
Marathon Digital (MARA)	2020-2021	3,634.09%
Nuvve (NVVEW)	2020-2021	3,583.33%
HIVE Blockchain Technologies (HIVE)	2020-2021	3,541.38%
American Lithium Corp Common Stock (AMLI)	2020-2021	3,541.3%
Novavax (NVAX)	2020-2021	3,485.71%
American Battery Technology Company Common Stock (ABAT)	2020-2021	3,243.75%
374Water Inc Common Stock (SCWO)	2020-2021	3,066.67%
Graf Industrial Corp Warrants (each warrant exercisable for one-half of one share of common stock each at an exercise price of $1150 per share) (GRAF.WT)	2020-2021	2,944.83%
GameStop (GME)	2020-2021	2,316.78%
Lightwave Logic (LWLG)	2020-2021	2,025.71%
CPI Card (PMTS)	2020-2021	1,961.11%
Empire Petroleum (EP)	2020-2021	1,911.51%
Riot Blockchain (RIOT)	2020-2021	1,858.77%
Vaxart (VXRT)	2020-2021	1,771.64%
Zivo Bioscience (ZIVO)	2020-2021	1,639.39%
Celldex Therapeutics (CLDX)	2020-2021	1,625%
Soluna (SLNH)	2020-2021	1,503.58%
Bit Digital (BTBT)	2020-2021	1,500%
Celsius (CELH)	2020-2021	1,443.89%