Enphase Energy (ENPH) had the highest return between 2019 and 2021 by a US stock in the S&P 500 (GSPC), returning 3,851.2%.

ASSET	YEARS	% RETURN
Enphase Energy (ENPH)	2019-2021	3,851.19%
Tesla (TSLA)	2019-2021	1,626.2%
Moderna (MRNA)	2019-2021	1,601.14%
NVIDIA (NVDA)	2019-2021	806.33%
Builders FirstSource (BLDR)	2019-2021	704.03%
Advanced Micro Devices (AMD)	2019-2021	699%
Generac (GNRC)	2019-2021	622.04%
EPAM Systems (EPAM)	2019-2021	487.44%
Lam Research (LRCX)	2019-2021	464.58%
Teradyne (TER)	2019-2021	443.87%
Fortinet (FTNT)	2019-2021	424.06%
KLA-Tencor (KLAC)	2019-2021	418.52%
Applied Materials (AMAT)	2019-2021	410.49%
Blackstone (BX)	2019-2021	396%
West Pharmaceutical Services (WST)	2019-2021	389.68%
Apple (AAPL)	2019-2021	372.37%
Carrier Global (CARR)	2019-2021	360.98%
DexCom (DXCM)	2019-2021	358.89%
Old Dominion Freight Line (ODFL)	2019-2021	348.19%
Synopsys (SNPS)	2019-2021	347.37%
Monolithic Power Systems (MPWR)	2019-2021	346.83%
Cadence Design Systems (CDNS)	2019-2021	336.93%
MSCI (MSCI)	2019-2021	334.97%
Freeport-McMoran Copper & Gold (FCX)	2019-2021	328.61%
ON Semiconductor (ON)	2019-2021	320.82%