Avalon GloboCare (ALBT) had the highest return between 2018 and 2022 by a US stock, returning 487,400%.

ASSET	YEARS	% RETURN
Avalon GloboCare (ALBT)	2018-2022	487,400%
Immatics (IMTX)	2018-2022	174,100%
AppTech Payments Corp Warrant (APCXW)	2018-2022	140,200%
Fresh2 (FRES)	2018-2022	83,026.11%
Alarum Technologies (ALAR)	2018-2022	19,412.2%
Kaival Brands Innovations (KAVL)	2018-2022	14,858.33%
Enphase Energy (ENPH)	2018-2022	10,986.19%
NAYA Biosciences (NAYA)	2018-2022	5,335.9%
Applied Digital (APLD)	2018-2022	5,011.11%
Xpel (XPEL)	2018-2022	4,100%
Zivo Bioscience (ZIVO)	2018-2022	2,817.15%
Nocera (NCRA)	2018-2022	2,465.13%
FitLife Brands, Inc Common Stock (FTLF)	2018-2022	2,452%
HighPeak Energy (HPKEW)	2018-2022	2,236.36%
Graf Industrial Corp Warrants (each warrant exercisable for one-half of one share of common stock each at an exercise price of $1150 per share) (GRAF.WT)	2018-2022	2,208.78%
Teekay Tankers (TNK)	2018-2022	2,143.58%
374Water Inc Common Stock (SCWO)	2018-2022	2,100%
Celsius (CELH)	2018-2022	1,855.68%
Empire Petroleum (EP)	2018-2022	1,821.97%
Tandem Diabetes Care (TNDM)	2018-2022	1,812.77%
Sigma Lithium Resources (SGML)	2018-2022	1,802.9%
Impact BioMedical (IBO)	2018-2022	1,634.72%
Golden Matrix (GMGI)	2018-2022	1,593.33%
Accolade (ACCD)	2018-2022	1,316.36%
Xenon Pharmaceuticals (XENE)	2018-2022	1,308.21%