Azitra (AZTR) had the highest return in 2023 by a US stock, returning 492,757.1%.

ASSET	YEAR	% RETURN
Azitra (AZTR)	2023	492,757.14%
MDxHealth SA ADR (MDXH)	2023	393,900%
JIN MEDICAL INTERNATIONAL LTD Ordinary Shares (ZJYL)	2023	3,000.63%
Cipher Mining (CIFRW)	2023	2,206.67%
Soleno Therapeutics (SLNO)	2023	1,825.84%
Pinstripes Holdings Inc WT (PNST.WT)	2023	1,376%
iCoreConnect Inc Common stock (ICCT)	2023	1,293.26%
Carvana (CVNA)	2023	1,000.62%
Applied Opt (AAOI)	2023	895.88%
Myomo (MYO)	2023	854.29%
American Coastal Insurance (ACIC)	2023	767.82%
Regis Corporation Common Stock (RGS)	2023	687.5%
Neuropace (NPCE)	2023	647.1%
Urgently Inc Common Stock (ULY)	2023	641.69%
Cipher Mining (CIFR)	2023	614.53%
Bit Digital (BTBT)	2023	582.26%
Bitfarms (BITF)	2023	567.43%
Marathon Digital (MARA)	2023	556.15%
Bone Biologics Corp Warrants (BBLGW)	2023	553.33%
Eyepoint Pharmaceuticals (EYPT)	2023	550.99%
QXO (QXO)	2023	525.37%
Direct Digital (DRCT)	2023	495.2%
Digihost Technology (DGHI)	2023	472.93%
MoonLake Immunotherapeutics (MLTX)	2023	469.72%
Olema Pharmaceuticals (OLMA)	2023	465.73%