Soleno Therapeutics (SLNO) had the highest return in Q3 2023 by a small-cap US stock, returning 604.3%.

ASSET	QUARTER	% RETURN
Soleno Therapeutics (SLNO)	Q3 2023	604.3%
Taysha Gene Therapies (TSHA)	Q3 2023	371.64%
Tango Therapeutics (TNGX)	Q3 2023	241.21%
Akso Health Group ADR (AHG)	Q3 2023	204.76%
Groupon (GRPN)	Q3 2023	160.54%
Belite Bio Inc ADR (BLTE)	Q3 2023	128.32%
Neuropace (NPCE)	Q3 2023	120.14%
Matrix Service (MTRX)	Q3 2023	99.66%
Canopy Growth (CGC)	Q3 2023	95.16%
Tetra Technologies (TTI)	Q3 2023	89.32%
MoneyLion (ML)	Q3 2023	80.33%
Nextnav Acquisition (NN)	Q3 2023	79.09%
Up Fintech (TIGR)	Q3 2023	78.4%
Applied Opt (AAOI)	Q3 2023	75.38%
Centrus Energy (LEU)	Q3 2023	74.11%
Seneca Foods Corp B (SENEB)	Q3 2023	72.61%
Wheels Up Experience (UP)	Q3 2023	71.07%
Heritage Insurance Hldgs (HRTG)	Q3 2023	69.9%
MillerKnoll (MLKN)	Q3 2023	66.71%
Hallador Energy (HNRG)	Q3 2023	65.94%
American Coastal Insurance (ACIC)	Q3 2023	65.39%
Seneca Foods Corp A (SENEA)	Q3 2023	63.92%
ASP Isotopes Inc Common Stock (ASPI)	Q3 2023	63.79%
Wave Life Sciences (WVE)	Q3 2023	58.4%
HighPeak Energy (HPKEW)	Q3 2023	57.69%

Small-cap stocks are treated as having a market cap between $300M and $2B.