Immatics (IMTX) had the highest return between 2016 and 2022 by a small-cap US stock, returning 174,100%.

ASSET	YEARS	% RETURN
Immatics (IMTX)	2016-2022	174,100%
Zhihu Inc ADR (ZH)	2016-2022	106,749.32%
Xpel (XPEL)	2016-2022	5,620%
SilverCrest Metals (SILV)	2016-2022	5,266.73%
P10 (PX)	2016-2022	2,911.48%
Gravity (GRVY)	2016-2022	2,404.35%
Centrus Energy (LEU)	2016-2022	2,360.61%
Applied Blockchain (APLD)	2016-2022	2,258.97%
HighPeak Energy (HPKEW)	2016-2022	2,236.36%
Sigma Lithium Resources (SGML)	2016-2022	1,802.9%
SIGA Technologies (SIGA)	2016-2022	1,566.38%
Cronos (CRON)	2016-2022	1,430.12%
Lithium Americas (Argentina) (LAAC)	2016-2022	1,356.99%
HIVE Blockchain Technologies (HIVE)	2016-2022	1,340%
Semler Scientific (SMLR)	2016-2022	1,246.94%
BlueLinx (BXC)	2016-2022	1,216.61%
Perpetua Resources (PPTA)	2016-2022	1,186.34%
Daqo New Energy Corp ADR (DQ)	2016-2022	1,078.57%
SolarEdge Technologies (SEDG)	2016-2022	994.55%
Wheels Up Experience (UP)	2016-2022	967.36%
Aehr Test Systems (AEHR)	2016-2022	963.49%
Kenon (KEN)	2016-2022	949.84%
RCI Hospitality (RICK)	2016-2022	886.26%
NAPCO Security Technologies (NSSC)	2016-2022	849.22%
Ameresco (AMRC)	2016-2022	841.35%

Small-cap stocks are treated as having a market cap between $300M and $2B.