Monster Beverage (MNST) had the highest return between 2000 and 2010 by a US stock in the S&P 500 (GSPC), returning 9,668.4%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2000-2010	9,668.39%
Deckers Outdoor (DECK)	2000-2010	9,015.23%
CarMax (KMX)	2000-2010	2,733.78%
Tractor Supply (TSCO)	2000-2010	2,335.11%
Tapestry (TPR)	2000-2010	2,156.48%
Netflix (NFLX)	2000-2010	2,070.53%
ANSYS (ANSS)	2000-2010	1,814.34%
Cognizant Technology Solutions Corp Class A (CTSH)	2000-2010	1,495.46%
DaVita HealthCare Partners (DVA)	2000-2010	1,444.22%
Old Dominion Freight Line (ODFL)	2000-2010	1,406.14%
NVR (NVR)	2000-2010	1,347.16%
Intuitive Surgical (ISRG)	2000-2010	1,332.02%
Hologic (HOLX)	2000-2010	1,195.07%
JB Hunt Transport Services (JBHT)	2000-2010	1,151.38%
BlackRock (BLK)	2000-2010	1,141.38%
Apple (AAPL)	2000-2010	1,130.24%
Occidental Petroleum (OXY)	2000-2010	1,107.33%
Cummins (CMI)	2000-2010	1,065.7%
EOG Resources (EOG)	2000-2010	1,020.46%
Edwards Lifesciences (EW)	2000-2010	960.22%
Wynn Resorts (WYNN)	2000-2010	931.03%
Ametek (AME)	2000-2010	920.33%
Gilead Sciences (GILD)	2000-2010	914.98%
Laboratory Corporation of America (LH)	2000-2010	853.63%
CoreSite Realty (COR)	2000-2010	850.48%