MDxHealth SA ADR (MDXH) had the highest return in 2023 by a US stock in the Nasdaq Composite (IXIC), returning 393,900%.

ASSET	YEAR	% RETURN
MDxHealth SA ADR (MDXH)	2023	393,900%
JIN MEDICAL INTERNATIONAL LTD Ordinary Shares (ZJYL)	2023	3,000.63%
Soleno Therapeutics (SLNO)	2023	1,825.84%
iCoreConnect Inc Common stock (ICCT)	2023	1,293.26%
Applied Opt (AAOI)	2023	895.88%
American Coastal Insurance (ACIC)	2023	767.82%
Regis Corporation Common Stock (RGS)	2023	687.5%
Neuropace (NPCE)	2023	647.1%
Urgently Inc Common Stock (ULY)	2023	641.69%
Cipher Mining (CIFR)	2023	614.53%
Bit Digital (BTBT)	2023	582.26%
Bitfarms (BITF)	2023	567.43%
Marathon Digital (MARA)	2023	556.15%
Eyepoint Pharmaceuticals (EYPT)	2023	550.99%
Direct Digital (DRCT)	2023	495.2%
Digihost Technology (DGHI)	2023	472.93%
MoonLake Immunotherapeutics (MLTX)	2023	469.72%
Olema Pharmaceuticals (OLMA)	2023	465.73%
Iris Energy (IREN)	2023	445.8%
Tourmaline Bio (TRML)	2023	445.72%
CleanSpark (CLSK)	2023	425.24%
BridgeBio Pharma (BBIO)	2023	418.89%
Ebang International (EBON)	2023	415.15%
Affirm (AFRM)	2023	390.42%
Gyre Therapeutics (GYRE)	2023	385.37%