Palantir Technologies Inc Class A Common Stock (PLTR) has had the highest return between 2024 and 2025 by a mega-cap US stock, returning 453.3%.

ASSET	YEARS	% RETURN
Palantir Technologies Inc Class A Common Stock (PLTR)	2024-2025	453.27%
NVIDIA (NVDA)	2024-2025	106.16%
Netflix (NFLX)	2024-2025	101.38%
Philip Morris International (PM)	2024-2025	84.29%
Walmart (WMT)	2024-2025	80.47%
SAP SE ADR (SAP)	2024-2025	72.41%
T-Mobile US (TMUS)	2024-2025	66.4%
Broadcom (AVGO)	2024-2025	59.16%
International Business Machines (IBM)	2024-2025	52.98%
Costco Wholesale (COST)	2024-2025	52.75%
Taiwan Semiconductor Manufacturing (TSM)	2024-2025	51.09%
Eli Lilly and (LLY)	2024-2025	45.91%
Berkshire Hathaway (BRK.B)	2024-2025	45.43%
Alibaba (BABA)	2024-2025	44.38%
Berkshire Hathaway (BRK.A)	2024-2025	44.36%
Facebook (META)	2024-2025	43.41%
JPMorgan Chase (JPM)	2024-2025	42.05%
Wells Fargo (WFC)	2024-2025	36.08%
Coca-Cola (KO)	2024-2025	28.89%
Visa Inc Class A (V)	2024-2025	28.15%
Oracle (ORCL)	2024-2025	25.33%
Abbott Laboratories (ABT)	2024-2025	23.15%
Mastercard (MA)	2024-2025	23.07%
Procter & Gamble (PG)	2024-2025	20.21%
Novartis AG ADR (NVS)	2024-2025	19.12%

Mega-cap stocks are treated as having a market cap of $200B+.